Chemical And Physical Properties Of Nucleic Acids Pdf

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chemical and physical properties of nucleic acids pdf

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Nucleic acid is an important class of macromolecules found in all cells and viruses. The functions of nucleic acids have to do with the storage and expression of genetic information. Deoxyribonucleic acid DNA encodes the information the cell needs to make proteins. A related type of nucleic acid, called ribonucleic acid RNA , comes in different molecular forms that participate in protein synthesis.

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Natural biochemical processes are routinely being discovered in living cells that involve RNA. Some of these processes, such as RNA interference, are now being exploited for biotechnology and medicinal applications. DNA has also proven in recent years to be more than a passive storehouse of information. For example, non-B-form DNA structures formed by G-rich DNA have been shown to participate in the regulation of gene expression, a discovery that presents new possibilities for drug targets in the genome. The current quest to understand how nucleic acid functions at the most fundamental level requires that we have a detailed understanding of nucleic acid-metal ion interactions. Because RNA and DNA are polyanions the structure and biological function of these biopolymers depends strongly on their association with metal ions.

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The physical and chemical properties of nucleic acids

These articles represent the very best NAR papers, in terms of originality, significance and scientific excellence. Articles offering reviews, analyses, insights, and opinions in areas relevant to the NAR audience. Read recent contributions. A comprehensive collection of methods papers published in Nucleic Acids Research since , listed by category. NAR publishes leading research fast, with an average of just 1.


DNA structure – basics, Watson-Crick and Hoogsteen base pairing, double helix, alternative structures, DNA superhelicity. • Chemical reactivity of DNA, DNA.


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Alongside proteins , lipids and complex carbohydrates polysaccharides , nucleic acids are one of the four major types of macromolecules that are essential for all known forms of life. The two DNA strands are known as polynucleotides as they are composed of simpler monomeric units called nucleotides. The nucleotides are joined to one another in a chain by covalent bonds known as the phospho-diester linkage between the sugar of one nucleotide and the phosphate of the next, resulting in an alternating sugar-phosphate backbone.

Steve Minchin, Julia Lodge; Understanding biochemistry: structure and function of nucleic acids. Essays Biochem 16 October ; 63 4 : — Nucleic acids, deoxyribonucleic acid DNA and ribonucleic acid RNA , carry genetic information which is read in cells to make the RNA and proteins by which living things function.

DNA Purification

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Introduction

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4 Comments

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    aspects of the physical and chemical properties of nucleic acids. Questions concerning the nature of ordered polynucleotide structures, and of the forces which.

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    PHYSICAL CHEMISTRY OF NUCLEIC ACIDS. Ignacio Tinoco, Jr. Since then a wide range of physical chemical methods have been applied to DNA and to its more In Bob Woody and I derived the optical properties.

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