Association Between Thiazide Diuretucs User And Risk Of Fracture At Elderly Age Pdf

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association between thiazide diuretucs user and risk of fracture at elderly age pdf

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Thiazide, a first-line therapy for hypertension, lowers blood pressure, increases bone mineral density, and reduces the risk of fractures. However, hyponatremia, an adverse effect of thiazide, is associated with increased risk of osteoporosis and fractures.

Thiazide Use and Fracture Risk: An updated Bayesian Meta-Analysis

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. The association between thiazide use and fracture risk is still controversial. We conducted an updated meta-analysis on the association between thiazide use and fracture risk.

Ятрогенний остеопороз. Частина І

Metrics details. Stroke is a major risk factor for osteoporosis and fractures. No study has evaluated the association between diuretic use and risk of vertebral fracture in stroke patients, although a considerable proportion of stroke patients are prescribed diuretics for hypertension. Our study aimed to investigate whether treatment with thiazides or loop diuretics affects the risk of vertebral fracture after stroke. A population-based propensity score-matched retrospective cohort study was conducted using the Taiwan National Health Insurance Research Database. Patients with a new diagnosis of stroke between and were included.

Osteoporosis and hypertension are frequent and often coexisting diseases among the elderly. Recent studies suggested that both diseases may share the same etiopathology. Moreover, the treatment of hypertension can affect the bone mineral density and worsen osteoporosis. The aim of this cross-sectional study was to assess the prevalence of low bone mass and osteoporosis in postmenopausal Syrian women and investigate their relationship with hypertension and antihypertensive drugs. Bone mineral density was measured using a dual-energy X-ray absorptiometry at the total lumbar spine L1-L4 and left hip. T-score values were used to determine the diagnosis of osteoporosis.

Javascript is currently disabled in your browser. Several features of this site will not function whilst javascript is disabled. Received 9 July Published 14 November Volume Pages — Review by Single anonymous peer review.

Thiazide Use and Fracture Risk: An updated Bayesian Meta-Analysis

Atenolol status at 1 month for the in-trial A and in-trial plus posttrial B cohorts. Initial curves for the in-trial A and in-trial plus posttrial B cohorts and curves from year 1 onward after randomization for the in-trial C and in-trial plus posttrial D cohorts. For the initial curves A and B , in the in-trial cohort, the unadjusted hazard ratio HR was 0. Hazards ratios HRs were adjusted for age, race, sex, diabetes, baseline estimated glomerular filtration rate eGFR , prevalent cardiovascular disease CVD , body mass index, and smoking. For estrogen, analyses are for women only.

Volume 9, Number 11, November , pages Background: An alleged association of chronic use of thiazide diuretics with an increased risk of bone fragility fractures has been highlighted by a relatively recent prospective cohort study. However, the concept that thiazides exert a beneficial effect on osteoporosis is still a predominant view. This effect would be mediated by the decrease in renal clearance of calcium ions, a pharmacological feature recognized for a long time now to this class of drugs, as opposed to the increase in calcium urinary excretion attributed instead to loop diuretics, i. The purpose of this retrospective study was to attempt to clarify whether regular use of thiazide diuretics as antihypertensive therapeutics is associated with a significantly increased risk of osteoporotic fractures in female patients aged 65 or over.

Every second in the United States, an older adult falls, making falls the No. In fact, more than 1 in 4 older people fall each year.

Coughlan T. Coughlan, F. DOI: Christiansen, S. Harrison, H.

Давайте же, ребята… уже миллион раз вы меня проверяли. Когда она приблизилась к последнему контрольно-пропускному пункту, коренастый часовой с двумя сторожевыми псами на поводке и автоматом посмотрел на номерной знак ее машины и кивком разрешил следовать. Она проехала по Кэнин-роуд еще сотню метров и въехала на стоянку С, предназначенную для сотрудников. Невероятно, - подумала она, - двадцать шесть тысяч служащих, двадцатимиллиардный бюджет - и они не могут обойтись без меня в уик-энд. Она поставила машину на зарезервированное за ней место и выключила двигатель.

Ему в голову пришла другая мысль.  - Вы дежурили все это время. - Моя смена от семи до семи, - кивнула женщина. - Тогда вы наверняка ее видели.

Он никогда не оставил бы жучков в своей программе. - Их слишком много! - воскликнула Соши, выхватив распечатку из рук Джаббы и сунув ее под нос Сьюзан.  - Смотрите.

Можно ли ему доверять. А не заберет ли он ключ. Фонтейну нужно было какое-то прикрытие - на всякий случай, - и он принял необходимые меры.

Так вот почему Дэвид отложил поездку в Стоун-Мэнор. - Сегодня утром я послал за ним машину. Он сказал, что позвонит тебе перед вылетом. Прости, я думал… - Зачем вы послали его в Испанию. Стратмор выдержал паузу и посмотрел ей прямо в .


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    between diuretic use and risk of vertebral fracture in stroke patients, although a used to calculate hazard ratios (HRs) of vertebral fractures among patients according to thiazide or loop diuretic use 13%, including prevalence as high as 20% in people aged without salaries such as students, children, elderly, and.

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